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Real Doctors (Life Makers)  |  Clinical  |  Medicine & medical subspecialities  |  Pathophysiology question « previous next »
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Author Topic: Pathophysiology question  (Read 6463 times)
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Pathophysiology question
« on: /September/ 30, 2005, 07:52:50 AM »

A patient with small cell carcinoma of the lung complains of muscle weakness , fatigue , confusion and weight gain . Physical examination is unremarkable . Serum sodium is found to be 120 mEq/L . Which of the following abnormal laboratory results would also be expected in this patient .

a-decreased plasma atrial natriutric peptide ( ANP) concentration
b-decreased plasma vasopressin concentration
c-decreased serum osmolarity
d-decreased urinary sodium concentration
e-increased plasma aldosterone concentration

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Re: Pathophysiology question
« Reply #1 on: /October/ 01, 2005, 04:39:51 AM »

I think this is SIADH and the correct answer is C? [decreased serum osmolarity].

the small cell carcinoma produces vasopressin (para malignant syndrome) leading to water retention , hyponatremia , dec. serum osmolarity , inc. Na excretion in urine , inc. urine osmolarity. renin and aldosterone level will be low as there is hypovolemia. I think ANP also will be low due to the hyponatremia.

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