Real Doctors (Life Makers)
Welcome, Guest. Please login or register.
/October/ 23, 2017, 06:31:26 PM
6115 Posts in 1589 Topics by 6180 Members
Latest Member: kz7tfriex4b
Latest Forum Topics: Basic Gunshot Wound Care First Aid  :-:-:-:-:-:-:-:  Ultimate USMLE Collection: Steps 1, 2 & 3 Videos, Books & Audiobooks  :-:-:-:-:-:-:-:  THE POST GRADUATE STUDY  :-:-:-:-:-:-:-:  Surgical Examination Videos  :-:-:-:-:-:-:-:  Pathoma for step 1  :-:-:-:-:-:-:-:  Huge Collection of Dental Videos, Books & applications !  :-:-:-:-:-:-:-:  Psychology Books Collection: 300+ Books  :-:-:-:-:-:-:-:   Vaccines: are they really safe & effective? [Video Collection]  :-:-:-:-:-:-:-:  The Ultimate Massage Thread: Huge Collection of Videos & Books about Massage  :-:-:-:-:-:-:-:  Manteca Chia - Full course of Taoist practice [1986-2007, DVDRip]  :-:-:-:-:-:-:-:  Natural Health - The Longevity Conference 2010 DVD Set  :-:-:-:-:-:-:-:  
Home Help Login Register

   * Clinical examination videos for Free

Clinical exam videos for free

Real Doctors (Life Makers)  |  Community complex  |  General Discussion  |  New Therapy For Asthma Is A Breath Of Fresh Air « previous next »
Pages: [1] Print
Author Topic: New Therapy For Asthma Is A Breath Of Fresh Air  (Read 4288 times)
Offline Offline

Posts: 599


New Therapy For Asthma Is A Breath Of Fresh Air
« on: /December/ 09, 2005, 11:13:02 PM »

Glucocorticoids, the treatment of choice for many people with asthma, boost production of the molecule IL-10, which helps decrease airway inflammation. However, some asthmatic patients are resistant to glucocorticoid therapy because their T cells do not produce IL-10 in response to these steroids. In a study appearing online on December 8 in advance of print publication in the January 2006 issue of the Journal of Clinical Investigation, Catherine Hawrylowicz and colleagues from King's College London investigate IL-10-producing T cells in the context of human allergic and asthmatic disease.

The authors show that pre-treatment of patient T cells with IL-10 and vitamin D3 can overcome this defect and greatly enhance glucocorticoid-induced IL-10 synthesis by T cells from asthmatic patients who were resistant to glucocorticoid therapy. These manipulations increase IL-10 production to levels comparable to those observed in patients who do respond well to therapy. IL-10 increases glucocorticoid receptor expression, and the authors propose that this is the mechanism by which IL-10 overcomes the glucocorticoid-resistant patient defect in IL-10 synthesis. Therefore, this population of IL-10-producing T cells may help treat human allergic diseases and reverse glucocorticoid resistance in asthma.

Journal of Clinical Investigation - Dec 8th
« Last Edit: /December/ 09, 2005, 11:15:02 PM by anwarica » Logged

Pages: [1] Print 
« previous next »
Jump to:  


| Tips club library