Real Doctors (Life Makers)
Welcome, Guest. Please login or register.
/October/ 23, 2017, 06:32:11 PM
6115 Posts in 1589 Topics by 6180 Members
Latest Member: kz7tfriex4b
Latest Forum Topics: Basic Gunshot Wound Care First Aid  :-:-:-:-:-:-:-:  Ultimate USMLE Collection: Steps 1, 2 & 3 Videos, Books & Audiobooks  :-:-:-:-:-:-:-:  THE POST GRADUATE STUDY  :-:-:-:-:-:-:-:  Surgical Examination Videos  :-:-:-:-:-:-:-:  Pathoma for step 1  :-:-:-:-:-:-:-:  Huge Collection of Dental Videos, Books & applications !  :-:-:-:-:-:-:-:  Psychology Books Collection: 300+ Books  :-:-:-:-:-:-:-:   Vaccines: are they really safe & effective? [Video Collection]  :-:-:-:-:-:-:-:  The Ultimate Massage Thread: Huge Collection of Videos & Books about Massage  :-:-:-:-:-:-:-:  Manteca Chia - Full course of Taoist practice [1986-2007, DVDRip]  :-:-:-:-:-:-:-:  Natural Health - The Longevity Conference 2010 DVD Set  :-:-:-:-:-:-:-:  
Home Help Login Register

   * Clinical examination videos for Free

Doctors and medical students

Real Doctors (Life Makers)  |  Clinical  |  Obstetrics & Gynecology  |  Question [IUCD] « previous next »
Pages: [1] Print
Author Topic: Question [IUCD]  (Read 5604 times)
dr_b.e.s.m
Administrator
*****
Offline Offline

Posts: 361

Doctor


Question [IUCD]
« on: /October/ 18, 2005, 12:44:45 AM »

IUD deacreases the risk of Which of the following cancers?

A ovarian
B breast
C cervical
D endometrial


and why?
Logged


 
dr_b.e.s.m
Administrator
*****
Offline Offline

Posts: 361

Doctor


Re: Question [IUCD]
« Reply #1 on: /October/ 24, 2005, 08:44:30 AM »

The correct answer is D. IUD showed decrease in endomet. cancer risk according to some studies.

"Six case-control studies from the US, Italy, and developing nations have explored the relationship of IUDs to endometrial cancer. Most found a reduced risk of endometrial cancer with IUD use, although not all results were statistically significant"? http://www.contraceptiononline.org/contrareport/article01.cfm?art=61



Possible explanation:
IUDs cause a foreign-body response in the uterine cavity. This reaction results in an increased number of mast cells, a reduced number of ciliated cells and impaired secretory activity in the epithelium near the device.
In addition, IUDs alter the endometrial response to estrogen and progesterone.


Some IUDs contain progesterone which of course protects against endometrial cancer but these studies talk about the ordinary IUD.


Some studies also show that IUD may reduce risk of cervical cancer too.

Any comments ?!!


« Last Edit: /October/ 24, 2005, 07:02:02 PM by dr_b.e.s.m » Logged
 
cleo_md
Administrator
*****
Offline Offline

Posts: 613



Re: Question [IUCD]
« Reply #2 on: /November/ 05, 2005, 11:34:56 AM »

I did a quick search Dr B.E.S.M at here are my results

I felt there has not been enough studies but so far it is agreed upon that IUD
use has been associated with lower risks of endometrial and cervical cancer
-

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
TI - Intra-uterine contraception and the risk of endometrial cancer.
AU - Castellsague X; Thompson WD; Dubrow R
SO - Int J Cancer 1993 Jul 30;54(6):911-6.

Despite the increasing world-wide popularity of contraceptive intra-uterine devices (IUDs), their potential long-term effects on the risk of developing endometrial carcinoma have been poorly studied. This paper reports on the relationship between intra-uterine contraception and endometrial cancer by analyzing epidemiological data from a large, multicenter, population-based, case-control study of epithelial endometrial cancer. Cases were 437 women, 20 to 54 years of age, with histologically confirmed epithelial endometrial cancer ascertained through 6 population-based cancer registries in the United States. Controls were 3200 women selected at random from the populations of these areas. The age- and parity-adjusted odds ratio (OR) for the association between ever having used intra-uterine contraception and endometrial cancer was 0.51 (95% confidence interval (CI) 0.3-0.Cool. Although the protective effect increased with duration of use, a dose-response relationship among users was not statistically demonstrable. The association did not vary significantly with age at first or last IUD use or with time elapsed since first or last IUD use. Years of education significantly modified the effect of intra-uterine contraception. Thus, intra-uterine contraception appeared to be strongly protective for women with at least 13 years of education (OR = 0.29, 95% CI, 0.15-0.6). It is proposed that intra-uterine contraception exerts its protective effect through local structural and biochemical changes in the endometrium that may alter endometrial sensitivity and response to circulating estrogen and progesterone.

AD - Servei d'Epidemiologia i Registre del Cancer, Universitaria de Bellvitge, Barcelona, Spain.
PMID- 8335399

--------------------------------------------------------------------------------


TI - Endometrial cancer in relation to intra-uterine device use.
AU - Hill DA; Weiss NS; Voigt LF; Beresford SA
SO - Int J Cancer 1997 Jan 27;70(3):278-81.

Data from a population-based case-control study were used to evaluate the risk of endometrial cancer among women who have used an intra-uterine device (IUD). Incident cases were identified between 1985 and 1991 among women aged 45-74 years who were residents of one of 3 counties in Washington State. Controls were selected by random digit dialing, and both groups of subjects received an in-person detailed interview. In this study population, women who had ever used an IUD were estimated to have a risk of endometrial cancer that was 0.61 times that of other women (95% CI 0.41-0.89). The reduction in cancer risk was not found to be dependent on duration of IUD use. There was a suggestion that women who had used intra-uterine contraception relatively late in reproductive life experienced a greater reduction in risk than those whose use was more distant or at a younger age. The relative risk among the small number of women who were currently using an IUD was 0.49 (95% CI 0.12-2.80). These results apply to the use of inert and copper IUDs as there was no use of progestin-releasing IUDs among women in the study population. The data from this and several other studies of the question support the hypothesis that use of an IUD has a favorable effect on the subsequent risk of endometrial cancer. The reason(s) for such a reduced risk is unclear.

AD - Department of Epidemiology, University of Washington, Seattle, USA.
PMID- 9033627

--------------------------------------------------------------------------------


TI - Intrauterine device use and risk of endometrial cancer.
AU - Parazzini F; La Vecchia C; Moroni S
SO - Br J Cancer 1994 Oct;70(4):672-3.

The relationship between intrauterine device (IUD) use and risk of endometrial cancer has been analysed in a case-control study conducted in Italy between 1983 and 1992, including 453 patients with histologically confirmed endometrial cancer and 1,451 controls admitted for acute, non-gynaecological, non-hormonal, non-neoplastic conditions to the same network of hospitals where cases had been identified. Two (0.4%) cases versus 36 (2.3%) controls reported ever using an IUD. The corresponding multivariate relative risk was 0.4 (95% CI 0.1-1.0). The results of this study and the few published available epidemiological data suggest a protective role of IUD use on endometrial carcinogenesis, but potential selective mechanisms for IUD utilisation (indication bias) should be carefully considered in the interpretation.

AD - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
PMID- 7917915

--------------------------------------------------------------------------------


TI - IUD use and the risk of endometrial cancer.
AU - Benshushan A; Paltiel O; Rojansky N; Brzezinski A; Laufer N
SO - Eur J Obstet Gynecol Reprod Biol 2002 Nov 15;105(2):166-9.

OBJECTIVE: Although the intrauterine device (IUD) is one of the most widely used forms of contraception throughout the world, its potential long-term effects on the uterus have not been thoroughly evaluated. This paper reports the long-term results of IUD use on the incidence of endometrial cancer. STUDY DESIGN: The data is part of a nationwide case-control, pilot study that was undertaken in order to evaluate the possible influence of ovulation induction drugs on the risk of endometrial cancer. The study included 128 living women 35-64 years old, with a histologically confirmed diagnosis of endometrial carcinoma. The controls were 255 women from the same dialing areas selected by random digit dialing. A multivariate logistic model, controlling for age, was used to assess the independent effects of factors found to be significantly associated with endometrial cancer on univariate analysis. RESULTS: The following parameters were found to be independently associated with endometrial cancer controlling for age: nulliparity OR=2.7 (95% CI 1.1-6.5, P=0.03); history of infertility OR=1.8 (95% CI 1.0-3.3, P=0.05); BMI>/=27 OR=2.3 (95% CI 1.4-3.8, P=0.001).The use of oral contraceptives and IUD were found to be protective; OR=0.29 and 0.37, respectively, (95% CI 0.14-0.61, P=0.001, 0.19-0.70, and 0.003, respectively). CONCLUSIONS: IUD use may have a protective effect on endometrial cancer risk. The protective effect of IUD may be either, through the intense inflammatory response that leads to other lisosomal and inflammatory actions, which may include cells responsible for early elimination of hyperplastic endometrial epithelial cells or, the more complete shedding of the endometrium associated with IUD use may decrease hyperplasia of the endometrium, a known risk factor for endometrial carcinoma.

AD - Department of Obstetrics and Gynecology, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel. benshushan@netscape.net
PMID- 12381481

--------------------------------------------------------------------------------


TI - Invasive cervical cancer and intrauterine device use.
AU - Lassise DL; Savitz DA; Hamman RF; Baron AE; Brinton LA; Levines RS
SO - Int J Epidemiol 1991 Dec;20(4):865-70.

Although the hypothesis that intrauterine device (IUD) use might promote cervical cancer has been considered since the introduction of IUDs in the early 1900s, previous studies are inconclusive. Data collected in interviews with 481 invasive cervical cancer cases and 801 general population controls from Birmingham, Chicago, Denver, Miami and Philadelphia were used to address this issue. These data were analysed to determine the relationship between IUD use and the risk of cervical cancer, with consideration of the type of IUD (copper and inert) and duration of use. A non-significant reduced risk of cervical cancer was associated with copper IUD use, indicated by an adjusted odds ratio (OR) of 0.6 (95% Cl: 0.3-1.2), but virtually no effect was found for inert IUD use (OR = 1.1, 95% Cl: 0.9-1.7). Decreased risk with increased duration of copper IUD use supports a possible protective effect of copper IUD use on the development of invasive cervical cancer.

AD - Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver.
PMID- 1800424
Logged
 
dr_b.e.s.m
Administrator
*****
Offline Offline

Posts: 361

Doctor


Re: Question [IUCD]
« Reply #3 on: /November/ 05, 2005, 02:07:35 PM »

yes Dr Cleo , you are right  , even the studies I posted before are not statistically segnificent ( according to the confidence interval). also I looked in books like current and found nothing mentioned about it , even on emedicine!
Logged
 
Pages: [1] Print 
« previous next »
Jump to:  


Google
 
Web www.real-doctors.com


| Tips club library